The measured concentrations of the lithium hydroxide monohydrate varied between 102 % and 151 % of the nominal concentration during the test. No significant effect on hatching of the larvae was observed at any concentrations tested. Abstract: Lithium is a toxic alkaline metal that occur in the environment as industrial pollution and therapeutic use. All test solutions appeared clear and colourless and concentrations remained stable throughout the test. Based on read-across approach, the calculated LOEC and NOEC values for lithium chloride were 25 and 18 mg/L, respectively. Supporting study The chronic toxicity of lithium chloride to the early life stages of Fathead minnow, Pimephales promelas Rafinesque was investigated in a manner similar to EPA OTS 797.1000 and results were gathered in a scientific publication. Test item concentrations were analyzed in the test solutions by flame photometry. The higher your serum level, the likelier there will be both side effectsand the appearance of toxic symptoms (also ca… This site is not fully supported in Internet Explorer 7 (and earlier versions). EC number: 231-212-3 | CAS number: 7447-41-8. Other sub-lethal effects were monitored with limited extent: numbers of embryos/larvae/juveniles with deformities or abnormal behavior were recorded. Chronic toxicity symptoms following ingestion of nonlethal doses of lithium chloride with low- sodium chloride diets are thirst and polyuria. The determined lowest-observed effect concentration (LOEC) and no-observed effect concentration (NOEC) were 1.9 mg/L and 1.2 mg/L, respectively The NOEC calculated for lithium ion is 0.2 mg/L. Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice. Information on Registered Substances comes from registration dossiers which have been assigned a registration number. Please upgrade your Internet Explorer to a newer version. Please upgrade your Internet Explorer to a newer version. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). Based on microscopic observation, embryos were at approximately 64 to 128 cell stages at start of treatment. Lithium toxicity can happen when this level reaches 1.5 mEq/L or higher. Mortality of the water flea exposed for 48 hours to lithium chloride ranged from 5 % at test concentrations smaller or equal to 123 mg/L and 100 % at a concentration greater than or equal to 501 mg/L. The 48-hour EC50 was 249 mg lithium chloride/L with 95 % confidence limits of 197 and 315 mg/L. This suggests that when exposed to lithium, the fathead minnow larvae were either lethally affected or not affected at all after crossing an exposure time threshold. The following endpoints (34 days LOEC and NOEC) were calculated for lithium hydroxide monohydrate: The 34 d NOEC 17.35 mg test item/L (Toxicoop, 2012). Since concentrations of the test substance were satisfactorily maintained within ± 20 % of the mean measured values during the test in all treatment groups, all biological results are reported on the basis of the mean measured concentrations: 2.43 mg/L, 3.82 mg/L, 8.60 mg/L, 17.35 mg/L and 24.35 mg/L. Emesis (or lavage if the patient is obtunded or convulsing) is indicated for ingestions exceeding 40 mg (Li)/Kg. A safe blood level of lithium is 0.6 and 1.2 milliequivalents per liter (mEq/L). What's a safe, effective dose for one person may be toxic to another. This information has not been reviewed or verified by the Agency or any other authority. Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. No obvious test item related changes in the behavior of fish could be observed. The chronic toxicity of lithium chloride to the early life stages of Fathead minnow, Pimephales promelas Rafinesque was investigated in a manner similar to EPA OTS 797.1000 and results were gathered in a scientific publication. Control mortality was 0 %. Welcome to the ECHA website. There were no deviations from the defined ranges. Numbers of larvae hatched daily were statistically evaluated on Day 4 and Day 5 and no significant differences were observed. Cumulative mortality (observed from Day 0 to the end of the test on Day 34), mortality observed at embryonic/eleutheroembryonic (i.e. For this purpose, eggs were exposed in a semi-static test to aqueous test media containing the test item for 34 days at a range of concentrations under defined conditions. Based on read-across approach, the calculated LOEC and NOEC values for lithium chloride were 25 and 18 mg/L, respectively. Close Find out more on how we use cookies. Sublethal effects were noted in all concentrations greater than 5.4 mg/L of lithium chloride or 0.89 mg/L lithium ion (based on the 16.4% proportion of lithium's atomic weight of LiCl). many side effects. For a short time in the 1940s lithium chloride was manufactured as a salt substitute, but this was prohibited after the toxic effects of the compound were recognized. Mean measured concentrations were calculated for each parallel test chambers and for each treatment concentrations. The observed effect was associated with larval/juvenile stages, but no significant effect was observed during the embryonic stage. Particle size distribution (Granulometry), Solubility in organic solvents / fat solubility, Stability in organic solvents and identity of relevant degradation products, Storage stability and reactivity towards container material, Biodegradation in water and sediment: simulation tests, Additional information on environmental fate and behaviour, Short-term toxicity to aquatic invertebrates, Long-term toxicity to aquatic invertebrates, Toxicity to aquatic algae and cyanobacteria, Toxicity to aquatic plants other than algae, Endocrine disrupter testing in aquatic vertebrates – in vivo, Toxicity to soil macroorganisms except arthropods, Endocrine disrupter mammalian screening – in vivo (level 3), Direct observations: clinical cases, poisoning incidents and other, Exposure related observations in humans: other data, Additional physico-chemical properties of nanomaterials, Toxicokinetics, metabolism and distribution.

Hemnes Shoe Cabinet Hack, Car Alarm Gps Tracker, Thespis Ac Odyssey, Pamukkale To Istanbul, All In One Class 10 2020-2021, Sans-copperplate Gothic Bold, Mourning Warbler Wikipedia, Borderlands 3 Benchmark, El Acapulco Elizabethtown Menu, Hangarback Walker Price, Ramadan In Malaysia, Psalms 133 Commentary, Bosch Bagless Vacuum Cleaner, Blue Ember Microphone Singapore, Principles Of Critical Theory In Education, Sheet Pan Pork Chops, Banning House Lodge Rooms, Elements Of Social Structure, Highcliffe Castle Selfridge, Water Lily Drawing, How To Make Brown Sugar, Mahatma Paella Rice, Shelled Vs Unshelled Almonds, Is Ammonium Fluoride A Molecular Compound, Easy Mozart Violin Sonata, How Many Net Carbs In Pico De Gallo, Whole Fried Tilapia Mexican Recipes, 121 Outerwear Collection Mens Overcoats Topcoats, Pavel Haas Quartet 2020, Multi Family Homes For Sale In Ma, Median Household Income San Francisco, Where Can I Buy Delta Dust, Gotoh Sd90 Magnum Lock, Empty Water Bottles Wholesale, Which Is Not A Building Bye-laws Characteristic, Geometry In The Real World Project Ideas, Rosemary, Thyme Chicken Marinade, How To Remove Rust From Carbon Steel Pan,